What were the advantages of Tesco choosing their business location where they did Essay Example

What were the advantages of Tesco choosing their business location where they did Essay Tesco put a substantial amount of money into researching the best place for their new stores and after this research was complete they decided upon an area in the Homend close to the train station. There used to be a factory on the same site but it had been shut down and had become a derelict. This was good for many reasons; one was that it was easy for them to get planning permission for a new store from the council because the derelict factory was an eyesore to a town priding itself on its natural beauty. As well as being easy to get the permission to build on the site it was also very cheap to purchase the land much for the same reason as before. The area of the town was also very advantageous to the store with regards to its market. The store was built in a place that is within walking distance for the people that live in the town and also has easy access because of the by-pass and it being on the outskirts of the town. What are the advantages of Tescos site choice now? We will write a custom essay sample on What were the advantages of Tesco choosing their business location where they did specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on What were the advantages of Tesco choosing their business location where they did specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on What were the advantages of Tesco choosing their business location where they did specifically for you FOR ONLY $16.38 $13.9/page Hire Writer When the research is being done it is important to think about the future, it would be disadvantageous for a business to build on the outskirts of a town because it allows easy access for the lorrys then 10 years later they are surrounded because of the towns growth. Tescos obviously thought to the future because the advantages are still pretty much the same as when they first moved there. Since the building of the Tesco store there has been a tremendous amount of growth pertaining to the new trading estate, because of the location of the store it has been very advantageous to it as the housing estate has been placing houses close to the store but never getting in the way of goods transport. This is largely to do with it being closely situated to the train station so new housing estates are encouraged to build away from these areas.

effects of wars essays

effects of wars essays The onset of WW I marked a turning point in the history of mankind, dramatically redefining the nature of warfare. The brutal restructuring of national policies to involve the entire nation, from industrial production to unwarranted assaults upon civilians, represents a tragic shift. The severity of this change warrants examination of both the general historical factors and specific events that produced such dire consequences, as well as speculation on whether WWI may have been avoided. Historians largely look toward two general trends of the late 19th and early 20th centuries. The rapid economic development and industrial growth that occurred in the 19th century, coupled with the diminishing availability of abundant resources, fostered a high sense of nationalism among Europeans. Nationalistic rivalries appeared throughout Europe. Britain jealously guarded its diminishing status as the world power, harboring much negative sentiment towards prosperous Germany. Meanwhile, under the lead of the militaristic Kaiser Wilhelm II, Germany attempted to rush its own emergence as an economic powerhouse. Kaiser Wilhelm, both jealous of being shut out of the colonial race and hoping to preserve Germany's rise, cultivated a large naval fleet. This only served to increase tensions with the British, as well as to threaten the French and drive them into a favorable relationship with Britain. Austria-Hungary, an empire rapidly losing its respected status, was also swept u p in the nationalistic fervor, with Archduke Franz Ferdinand's visit to Bosnia largely intended to assert his nation's power. The nationalistic fervor was fed by the absence of a large war involving any of the great powers in over fifty years. Even the most prominent political and military leaders lacked a true sense of what combat entailed. Most viewed war as some idealistic entity, nothing more than a way to heroically promote their interests. T...

Responses Essay Example | Topics and Well Written Essays - 500 words

Responses - Essay Example As far as the language is concerned, I felt it was not the language that hindered the communication between Yolanda and her partners rather it was the difference in cultural values and personality types that hindered their understanding of each other, the way I see it. Rudy had made himself quite clear and so had Yolanda that she needed some time and space in order to be more intimate with him. Yolanda’s fear of losing Rudy kept her from being very open with him in this matter as to the fact that she felt that there needed to be more to love than just sexual needs. Similarly with John, she was not able to tell him straight that she wanted more to their marriage than just physical attraction and that she wanted someone with whom she could talk to for hours. I also agree with the fact that the chapters we read do portray Yolanda’s quest for identity, just as â€Å"Their Eyes Were Watching God† describes the identity quest for Janie. Response to Kerriann Salatti: I like your mention of Joe and her confusion with the word love. This reminds me of her allergy which she tries so hard to overcome. This fact that she is determined to get over her allergy shows the strength of her character.

Implementation of RfId Technology in Libraries Research Paper

Implementation of RfId Technology in Libraries - Research Paper Example In addition, the paper will look at this by identifying the benefits of this form of technology to the libraries, then go to an extent of comparing these to the benefits, and make a decision. e. Motivation The development of technology and their applications to help make work easier in modern organization has motivated this research. Libraries have significantly remained in the rear in terms of equipment used in transmitting their services to the public and for effectiveness and usefulness in the classification of lent and borrowed books; the use of this knowledge is sought. The essay will begin by a foreword after which the synopsis of the knowledge is sought and after this, we will see the benefits of this technology to the libraries and couple with this is the identification of the obstacles faced when implementing this. A conclusion in form of decision or summary will ultimately follow. Overview of RFID technology Technological advancement is something good when it comes to the i mprovement required in performance and reduction of the costs. The development of this form of technology started all the way in 1945 when the British developed a simple form of the technology to help them in the identification of the aircrafts for the enemies and theirs. Between the 1960’s, and 70’s, the system was further developed for the security and safety of nuclear material and here the equipment and the personnel got tagged (Ngai et al, 2010). In 1977 this new knowledge was made for use by the civic sector, this was suggested by a group of conglomerates, and it is at this time and by the companies that several applications of this technology were explored. Partly, the motivation behind the development of the technology was the failure by the bar code in identification. In... The essay begins by a foreword after which the synopsis of the knowledge is sought and after this, we will see the benefits of this technology to the libraries and couple with this is the identification of the obstacles faced when implementing this. A conclusion in form of decision or summary will ultimately follow. Tis article makes a a conclusion that at the click of a mouse, RFID systems have enabled book tracking, customer compliance and most importantly, the safety of library workers. With all the benefits RFID technology provides, it is no wonder most libraries in the world today are choosing to embed RFID tags in their books as well as developing their own RFID safety systems. Like many technologies today, once libraries adopt the use of RFID systems, it is often hard for them to go back to initial systems because of the current efficiency they experience. The impact of information technology advancement is currently evident in every sector and field across the world. RFID technology is becoming more pervasive in the education sector and it is widely being used in libraries and has become a boon to the field of library, especially in relation to securing and library resources, archives and materials. There is need for the development of RFID technologies and infrastructure that are less c ostly in order to enhance their use in libraries. It is evident that RFID use in libraries poses serious privacy and security implications hence their need for the development of advance security protocols and procedures.

Reading Research Literature # 1 Assignment Example | Topics and Well Written Essays - 500 words

Reading Research Literature # 1 - Assignment Example Journal of General Internal Medicine, 28(3), 436-443. doi:10.1007/s11606-012-2234-y http://search.ebscohost.com.proxy.chamberlain.edu:8080/login.aspx?direct=true&db=rzh&AN=2012018670&site=ehost-live The purpose of this research is to carry out an examination of hospital discharge processes such as patient education for patients with acute myocardial infarction and identify which discharge processes may be useful in performance in medical facilities for hospitals AMI care. The research used qualitative study of US hospitals based on RSMR reports by CMS. Hospitals used ranked in top and bottom 5 % in consecutive two years as reported by RSMR. The method used was deviant case sampling. Data was collected using interviews and ground theory approach through visits to the 14 sites to the hospitals. The focus of the study was on hospitals that ranked in the top 5% and bottom 5% of RSMR. The hospitals chosen could be able to perform percutaneous intervention. The hospitals sample used was based on socioeconomic status, geographical and RSMR status. The sample was adequate for the research design because results could be deduced form it. Results showed that there were distinct differences in discharge processes between high and low performers in hospitals. Such results were only finalized due to the sample used. Ancheta, I. B. (2006). A retrospective pilot study. Dimensions of Critical Care Nursing, 25(5), 228-233. http://search.ebscohost.com.proxy.chamberlain.edu:8080/login.aspx?direct=true&db=rzh&AN=2009297932&site=ehost-live A pilot study was conducted under authority from HIPPA. 300 clinics records of patients were used in the investigation of the study. Data collected was demographic such as age, ethnic background, and marital status. The focus of the study was on the patients records that met the criteria of diagnosis of chronic stable CHF secondary to decreased systolic left ventricular dysfunction EF of less

Genetically Modified Plants And Animals Biology Essay

Genetically Modified Plants And Animals Biology Essay The genome of both animals and plants has been altered for many years through various traditional breeding methods and organisms with favourable characteristics have being artificially selected to breed successive generations. These methods, however, have been limited to naturally occurring variations. Recent advances in genetic engineering have made it possible for scientists to precisely control any genetic changes introduced into an organism. Genes from one species can, through genetic engineering, be incorporated into an entirely different species. Any organism which has had its genetic material altered is defined as a genetically modified organism (GMO). The definition states that a GMO includes any living organism that possesses a novel combination of genetic material obtained through the use of modern biotechnology. It is important to note that in the case of humans, even if they have had their genes altered as a result of, gene therapy for instance, they are not considered to be GMOs. A major purpose of the field of genetics is to classify genes according to their function. The scientific study of genes in living organisms can be separated into three different strategies. The first two, which analyse natural variation and random mutagenesis, are the primary methods of forward genetics where the genotype of an abnormal phenotype is studied. In the case of random mutagenesis, it is often difficult to trace a phenotype back to a specific gene as many chromosomal loci are simultaneously targeted. Thus a third type of research strategy, reverse genetic techniques, has been developed in the past three decades. This method, where a specific gene is modified and the phenotype is subsequently investigated, provided tools for the research of gene function in a targeted manner. Among the most frequently used animals are Drosophila melanogaster (fruit fly), Caenorhabditis elegans (nematode) and Mus musculus (house mouse), and plants Nicotiana tabacum (tobacco), Arabidopsis thaliana (thale cress) and Triticum aestivum (common wheat) which have each been essential for the identification of genes implicated in aging, cell differentiation, development, and other significant biological functions. Transgenic rats are of great importance in neuroscience as they have been extensively used in behavioural paradigms (Abbott 2004) while recently, the first transgenic primate disease model, for Huntingtons disease, was created (Yang et al. 2008). Research has progressed through the use of various techniques. One of these techniques is the loss of function method where an organism is modified so that one or more genes lose their activity. This method has allowed researchers to analyze defects caused by particular mutations and has been extremely useful in identifying the function of a gene. Another method is the knockout experiment which involves the creation and manipulation of a DNA construct in vitro. In a simple knockout, this construct contains a copy of the required gene which has been slightly changed to lose its function. The modified gene is then taken up by embryonic stem cells, and it replaces the organisms own gene. These stem cells are then injected into a blastocyst which is implanted into a surrogate mother. Furthermore, the gain of function method is frequently performed in conjunction with the knockout method so that the function of a desired gene can be more finely identified. The process is very similar to knockout engineering, but in this case the construct amplifies the function of the gene, by adding extra copies of the gene or inducing more frequent synthesis of the protein. Information on the localization and interaction of a protein can be obtained through tracking experiments. In this method the wild-type gene is replaced with a fusion gene, which is a combination of the wild-type gene with a reporting element such as Green Fluorescent Protein (GFP). The reporting element allows visualization of the products of the modification. Moreover, expression studies can display the time and location of the synthesis of the protein. In this technique the promoter is reintroduced into an organism but the coding region is replaced by a reporting element or an enzyme catalyzing the production of a dye. A further advancement in expression studies has been the process promoter bashing, where the promoter is altered so as to find which pieces are crucial for proper gene expression and are bound by transcription factor proteins. The use of these, and other, methods to investigate critical questions in genetics has become standard practice. In particular, GMOs have been essential for 1) Identifying a genes function and any molecular elements related to it; 2) Creating models of human diseases; 3) Determining and confirming drug targets and specificity and 4) Investigating chronological aspects of gene function. 1) Identifying a genes function and any molecular elements related to it Targeted mutagenesis has been used extensively in the field of neuroscience. One of the very first groundbreaking experiments using targeted mutagenesis was carried out by Eric Kandel at Columbia University. Using the tetracycline inducible system, they expressed a calcium-independent form of the calcium dependent kinase, calcium-calmodulin kinase II (CaMKII), which is specific for the forebrain. They also observed a decline in spatial memory and hippocampal long-term potentiation (LTP). This major breakthrough displayed how both temporal and spatial control over molecular elements can help to identify the function of a particular gene and its role in brain function. Plant modification techniques have been invaluable tools for genetic research. Through the use of these methods, geneticists have gained detailed knowledge on the function of specific plant genes, their expression and the properties of the proteins they encode. One important trait that has been studied using transgenic plants is plant mechanical strength, which has an agronomic significance. Transgenic rice from the Indica variety was used to elucidate the molecular mechanism controlling the mechanical strength of crops. Mutations on the BC1 gene, which is expressed mostly in developing sclerenchyma cells and vascular bundles, were introduced into rice and resulted in a decrease of cell wall thickness and cellulose content and an increase in lignin level. This suggested that BC1 has a vital role in the biosynthesis of the cell walls of mechanical tissues. 2) Creating models of human diseases Another significant use for GMOs is the development of models for human disorders. This can be done by introducing a mutated gene or eliminating a gene which has a putative role in the disease. GMOs have been tremendously useful in modelling a wide range of illnesses, especially in the field of neuroscience. These include Alzheimers disease (AD), Huntingtons disease, cerebral ischemia and neuropsychiatric disorders. AD, for instance, is characterized by the presence of neurofibrillary tangles formed by hyper-phosphorylated tau protein and by amyloid ÃŽÂ ²-peptide (AÃŽÂ ²) plaques. Mutations in the amyloid precursor protein (APP), apolipoprotein E (APOE) and presenilin 1 and 2 (PS1, PS2), have all been shown to have a role in the disease. Research on transgenic mice has indicated that an overexpression of APP and PS1 causes AÃŽÂ ² plaque formation and leads to memory deficits, which are both symptoms of AD. The significant role of GMOs in testing potential causal mechanisms o f human disease is consequently highlighted. Recently, researchers at The University of Western Ontario working with scientists in Brazil used a unique transgenic mouse line to discover a previously unknown mechanism causing heart failure. The study showed that if the release of the neurotransmitter acetylcholine, which decreases cardiac activity, is reduced the probability of heart failure increases (ScienceDaily, 2010). Fundamental discoveries made first in plants have been central in our understanding of human biology, specifically cells, genes, molecular chaperones, transposable elements, programmed cell death, and gaseous hormones. Research on  genetically modified A. thaliana has helped in the identification of genes involved in human disease.  Scientists have shown that eighty-eight genes on chromosome 5 of A. thaliana are very similar to the 289 genes linked to human disease syndromes which have been established for comparison with D. melanogaster. As the majority of these are also greatly conserved between D. melanogaster and C. elegans, A. thaliana biology can be modified and used as a model to increase our knowledge of human disease. Many of these genes encode proteins which have a conserved function. For example, DNA excision repair genes (linked to xeroderma pigmentosum) and ATP-dependent copper transporters (linked to Wilsons and Menkes disease). In the latter the A. thaliana homolog ue is more similar to the human homologue than to the D. melanogaster or C. elegans counterparts. 3) Determining and confirming drug targets and specificity The development of genetic models for diseases has greatly assisted in drug discovery and in identifying drug targets. Genetic modification can be extremely specific, for instance removing a gene which codes for a particular receptor subtype. This specificity ensures almost complete selectivity and is thus preferred to classical pharmacological approaches. For example, through the use of both the knock-in and knockout methods scientists can examine the function of receptor subtypes. Specifically, transgenic mice have been used to establish the purpose of specific GABA receptor subunits in the diverse actions of diazepam. Diazepam, a benzodiazepine, acts on GABAA receptors which consist of ÃŽÂ ±1-, ÃŽÂ ±2-, ÃŽÂ ±3-, or ÃŽÂ ±5- subunits. The mice where modified to carry point mutations in the benzodiazepine receptors of each of their subunits, and the investigators were thus able to genetically separate the distinct functions of diazepam (e.g. sedative or anxiolytic) acting at otherwise similar GABAA receptors. Plants are very significant as novel therapeutic drug leads. Nicotine, the main biologically active compound in N. tabacum, binds to the nicotinic acetylcholine receptors (nicAChRs) in the central nervous system (CNS) to produce a wide variety of biological effects. The nicAChR family consists of receptors made of ÃŽÂ ²-subunits and a series of structurally varied ÃŽÂ ±-subunits. The differences in the ÃŽÂ ±-subunit amino acids and in the subunit composition create variations in the receptors binding site and give the members of this receptor family unique drug specificity. Through the use of transgenic N. tabacum it was demonstrated that a significant number of the plants contained compounds that are selective for brain receptors linked to the a7 nicAChR. Compounds which have this selectivity are of particular interest as drugs that act on these receptors may be useful to treat degenerative brain diseases such as AD. 4) Determining and confirming drug targets and specificity In addition, GMOs have been used to analyse second messenger signaling pathways and also to determine vital developmental timing of gene function. The latter was demonstrated by using a tetracycline inducible knock-out of the serotonin 1A receptor. When the receptor was knocked out during development, it caused the knockout mouse to experience increased anxiety. When the receptor was knocked out in adults, however, the anxiety levels were normal. It was thus shown that the 1A receptor is associated to a developmental factor necessary for normal emotional behaviour. Transgenic plants have also been effectively used to analyze regulated gene expression, as the expression can be investigated at various stages and in different tissues. The environmental factors that influence gene expression and that have been studied in transgenic plants include temperature, light intensity, anaerobic stress, and wounding. The development of flowers requires the collaboration of specialized tissues. Research was carried out on transgenic petunia to determine the genes controlling the development and differentiation in the flower. By analysing the 5-enolpyruvylshikimate-3-phosphate synthase gene, which is found in high concentrations in flowers, the researchers were able to identify an upstream region that is responsible for the tissue-specific and developmentally regulated expression. Conclusion In summary, this technology has played a considerable role in genetics. The most common applications of GMOs in the field of genetics have been highlighted: dissecting biological mechanisms, modelling human diseases, discovering and validating pharmaceuticals, and investigating crucial time windows in gene function. While there are many other types of approaches for creating GMOs and many other uses for these organisms, the role of GMOs in genetics has being the main focus, as the impact on this field has been substantial. New approaches to creating and using GMOs are continuously being developed, including adjustments and combinations of the discussed techniques, which will surely further impact genetics.

The Language Behind Dawkins’ Selfish Gene Theory :: Science Selfish Gene Theory Essays

The Language Behind Dawkins’ Selfish Gene Theory According to Michael Polanyi, our understanding of a concept depends in part on the language we use to describe it. Connie Barlow's book, From Gaia to Selfish Genes, looks at metaphors in science as integral parts of some new biological theories. One example is Richard Dawkins' theory about the selfish gene, where he claims that the most basic unit of humanity, the gene, is a selfish entity unto itself that exists outside the realm of our individual good and serves its own distinct purpose. Dawkins looks at the evolutionary process, how DNA replicates in forming human life, and the possibility that there is a social parallel to genetics, where human traits can be culturally transmitted. Dawkins, in the excerpts that Barlow has chosen, uses heavily metaphoric language to explain these scientific concepts to the general public. However, the language that Dawkins uses, while thought provoking, also carries some negative implications that extend beyond his theory. The selfish gene theory has many positive aspects, but its metaphors detract in certain ways from the scientific message of Richard Dawkins. The metaphor behind Dawkins' theory can best be described by his opening statement: "we are survival machines-robot vehicles blindly programmed to preserve the selfish molecules known as genes" (Barlow 193). Dawkins links the natural behavior of unconscious bunches of nucleic acid (genes) to human behavior and personality by calling them "selfish." His use of this term conjures up the image of a separate individual, capable of making decisions to help its own good and disregarding our needs. By calling human beings "survival machines" and "robots," Dawkins suggests some serious moral implications regarding our existence. If we were just robots, it would seem that we would be no longer responsible for our actions, as people could attribute all evil to the gene programmers who created these robots. Also, if our primary purpose were to serve as a "survival machine" for something else, life would seem insignificant. John Maynard Smith writes that Dawkins' book is just about evolution , and "not about morals . . . or about the human sciences" (195). However, the attempt to disengage the selfish gene theory from its moral implications is seriously undermined by Dawkins' metaphors. The origin of the selfish gene, and of evolution itself, began in something Dawkins calls the "primeval soup," where protein molecules, by pure chance, bonded together to form "replicators," the ancestors of DNA (198).